(often with at) To lash out; to strike or hit at someone or something, particularly something in arm's length of the striker and at or near the level of the striker's head.
To strongly criticize or make a verbal attack, particularly as a response to previous criticism or provocation.
To draw a line through some text such as a printed or written sentence, with the purpose of deleting that text from the rest of the document.
To treat something as settled
Of a batter, to be retired after three strikes (missed swings, as opposed to any other way of becoming "out"); of a pitcher, to cause this to happen to the batter.
Jones struck out on a nasty slider.
To fail; to be refused a request or to have a proposal not be accepted, in particular a request for a (hopefully romantic) date.
Dave asked the new girl to the dance but he struck out.
To begin to make one's way.
The travellers struck out towards the line of mountains.